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b6 Cell Biology, Physiology, and Metabolism Faculty

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All CAMB Faculty | CB Faculty | CPM Faculty | DSRB Faculty | G&E Faculty | GTV Faculty | MVP Faculty

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The Program in Cell Biology, Physiology, and Metabolism is dedicated to training graduate students in the diversity of medical science that defines modern cell biology, as well as providing ample time and resources for specializations.

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7a 44 7 41 Cell Biology, Physiology and Metabolism Members 5a a 1 7 1 1 33

Current Members

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Cell Biology, Physiology and Metabolism

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Click the faculty member's name to see more detailed information.

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Faculty

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Research Topics

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FacultyBrief Research Description
Zoltan Pierre AranyCardiovascular metabolism
Will BailisImmune Cell Metabolism
Joseph A. BaurMolecular mechanisms of aging
Joshua DunaiefRetinal iron trafficking and its role in retinal disease
J. Kevin FoskettIon channels, calcium signaling, cystic fibrosis.
David Frank 62

Cellular and molecular mechanism of pulmonary vascular growth, disease, and homeostasis

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Thomas JongensModeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Daniel KellyTranscriptional and epigenetic control of mitochondrial function; nuclear receptor signaling in the developing and diseased heart; molecular mechanisms controlling muscle metabolic fitness.
Mitchell LazarRegulation of gene expression and metabolism by nuclear hormone receptors.
Robert LeeEpithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Virginia LeeTau, a-synuclein and amyloid beta precursor protein (APP), and their roles in the pathobiology of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson’s disease (PD), and frontotemporal dementias (FTD).
Fanxin LongEnergy metabolism in skeletal cell types under normal or pathological conditions
Damaris LorenzoCytoskeleton and membrane adaptors in metabolic processes using cell and mouse models.
Benjamin L. ProsserCardiac electrophysiology; excitation-contraction coupling; calcium signaling; mechanotransduction; redox signaling
Christoph Thaiss 72

Body-brain communication in aging, cancer, inflammatory, cardiovascular, and neurodegenerative diseases

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Paul TitchenellMolecular mechanisms of insulin signaling and insulin resistance
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FacultyBrief Research Description
Erfei BiDevelopment of cell polarity and control of cytokinesis in budding yeast.
Janis BurkhardtCytoskeletal control of immune cell function, leukocyte adhesion and motility, cell mechanics, membrane-cortex attachment, TCR and integrin signaling.
Dennis DischerCell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery.
Jonathan EdwardsRight ventricular heart failure, pediatric heart Failure, proteostasis
Yale GoldmanRelating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors.
Ekaterina L. GrishchukMechanisms that drive and control chromosome motions in mitosis
Wei GuoThe molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Erika L. HolzbaurMicrotubule-based motility.
Paul JanmeyCytoskeleton, phosphoinositide signalling, cell mechanics.
Thomas JongensModeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Anna S. KashinaProtein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Michael LampsonCell division, selfish centromeres and centromere evolution, germline epigenetic inheritance
Damaris LorenzoCytoskeleton and membrane adaptors in cellular and organism metabolism.
Frank LucaYeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth. Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).
Guilherme NaderNuclear mechanosensing pathways during cell migration and invasion
Michael OstapMolecular mechanisms of cell motility.
Benjamin ProsserMechano-signaling in heart
Arndt Siekmann 83

Development of the vascular system with a focus on investigating the mechanisms leading to arterial-venous malformations

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Tatyana SvitkinaRoles of the cytoskeleton in cell motility.
Phong TranThe cytoskeleton and cellular pattern formation.
John W. WeiselIntermolecular and cellular interactions in blood clotting, fibrinolysis, and atherosclerosis studied by molecular biophysical methods.
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FacultyBrief Research Description
Zoltan Pierre AranyCardiovascular metabolism
Yair ArgonFunctions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation
Joseph A. BaurMolecular mechanisms of aging
Erfei BiDevelopment of cell polarity and control of cytokinesis in budding yeast
Janis BurkhardtCytoskeletal control of immune cell function, leukocyte adhesion and motility, cell mechanics, membrane-cortex attachment, TCR and integrin signaling
Natali ChanadayMolecular mechanisms of neuronal communication
Margaret ChouMechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination
Andy DancisIron transport into mitochondria, Heme synthesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia
Carol DeutschFunction and assembly of potassium channels in human T lymphocytes
Robert DomsHIV; Emerging viral pathogens; Cell biology of Alzheimer's disease
J. Kevin FoskettIon channels, calcium signaling, cystic fibrosis. 
Yale GoldmanRelating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors.
Wei GuoThe molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Erika L. HolzbaurMicrotubule-based motility.
Paul JanmeyCytoskeleton, phosphoinositide signaling, cell mechanics.
Thomas JongensModeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Kelly Jordan-Sciutto 97

Impact of neuroinflammation on viability, differentiation and function of oligodendrocytes and neurons in the context of neurodegeneration
61 Role of organellar stress in cellular response to neuroinflammation in cells of the CNS
6e Use of induced pluripotent stem cells and 3-D organoids to model neuroinflammation induced CNS effects

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Anna S. KashinaProtein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Damaris LorenzoCytoskeleton and membrane adaptors in cellular and organism metabolism.
Frank LucaYeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth. Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).
Michael S. MarksRegulation and diseases of intracellular protein transport and organelle biogenesis.
Michael OstapMolecular mechanisms of cell motility.
Mechthild PohlschroderProkaryotic protein translocation across hydrophobic membranes.
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FacultyBrief Research Description
Natali Chanaday 39

Molecular mechanisms of neuronal communication

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Carol DeutschFunction and assembly of potassium channels in human T lymphocytes.
Josuha DunaiefRetinal iron trafficking and its role in retinal disease
J. Kevin FoskettIon channels, calcium signaling, cystic fibrosis.
Robert LeeEpithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Damaris LorenzoCytoskeleton and membrane adaptors in cellular and organism metabolism.
Zhe LuMolecular and biophysical mechanisms of ion channels.
Minghong MaNeurobiology of the sense of smell
Dejian RenRegulation of cellular excitability by ion channels and calcium signaling.
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10 9 7 20 33 8 7 17 8d 8 7 1e 26 8 7 1c a2 8 7 1c 8 8 7 1a 85 8 7 1b 101 8 7 1d 53 8 7 1d 3e 8 7 18 8 8 7 18 47 8 7 1b 59 8 7 21 8 8 7 16 3f 8 7 1c 6b 8 7 17 fc 8 7 18 8 8 7 1c 54 8 7 1c 4f 8 7 1d 8 8 7 1c 4d 8 7 1c 5f 8 7 1a 57 8 a 9
FacultyBrief Research Description
Yair ArgonFunctions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation.
Lawrence F. BrassMechanisms of thrombosis.
Janis BurkhardtCytoskeletal control of immune cell function, leukocyte adhesion and motility, cell mechanics, membrane-cortex attachment, TCR and integrin signaling
Natali Chanaday 39

Molecular mechanisms of neuronal communication

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Margaret ChouMechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination.
Dennis DischerCell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery.
Jonathan EdwardsRight ventricular heart failure, pediatric heart Failure, proteostasis
J. Kevin FoskettIon channels, calcium signaling, cystic fibrosis.
David Frank 62

Cellular and molecular mechanism of pulmonary vascular growth, disease, and homeostasis

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Paul JanmeyCytoskeleton, phosphoinositide signalling, cell mechanics.
Thomas JongensModeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Kelly Jordan-Sciutto 97

Impact of neuroinflammation on viability, differentiation and function of oligodendrocytes and neurons in the context of neurodegeneration
61 Role of organellar stress in cellular response to neuroinflammation in cells of the CNS
6e Use of induced pluripotent stem cells and 3-D organoids to model neuroinflammation induced CNS effects

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Mark KahnSignaling pathways in angiogenesis and hemostasis.
Michael LampsonMitotic kinase signaling, chromosome segregation in mitosis and meiosis, kinetochore function.
Robert LeeEpithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Fanxin Long 50

Metabolic reprogramming by growth factor signaling in skeletal cells.

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Damaris LorenzoCytoskeleton and membrane adaptors in cellular and organism metabolism.
Guilherme NaderNuclear mechanosensing pathways during cell migration and invasion
Christoph Thaiss 72

Body-brain communication in aging, cancer, inflammatory, cardiovascular, and neurodegenerative diseases

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Paul TitchenellMolecular mechanisms of insulin signaling and insulin resistance
Stefano RivellaMolecular mechanisms that control erythropoiesis, iron metabolism and inflammation
Rebecca WellsTGF-ß receptor biology; Hepatic stellate cell function in liver fibrosis.
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For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.

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