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a6 Genetics and Epigenetics Faculty
1d 21 41 21 41 166All CAMB Faculty | CB Faculty | CPM Faculty | DSRB Faculty | G&E Faculty | GTV Faculty | MVP Faculty
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1 1 1 48Faculty
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Naiara Akizu, Ph.D.
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Qin Li, PhD
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Defne Amado, MD, PhD
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Yoseph Barash, Ph.D.
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Ben E. Black, Ph.D.
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Maja Bucan, Ph.D.
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Luca Busino, Ph.D.
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Liming Pei, Ph.D.
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Yuyan Cheng, Ph.D.
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Xuyu Qian, PhD
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Daniel J Rader, MD
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Peter S. Choi, Ph.D.
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Arjun Raj, PhD
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Shinjae Chung, Ph.D.
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Bushra Raj, Ph.D.
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Colin Conine, PhD
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Crystal S. Conn, PhD
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Kavitha Sarma, Ph.D.
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Pablo G Cámara, PhD
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Sharlene M. Day, MD
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Ophir Shalem, Ph.D.
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Yanxiang Deng, PhD
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Junwei Shi, Ph.D.
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Hongjun Song, Ph.D.
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Yuanquan Song, Ph.D.
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Ziyue Gao, PhD
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Yijing Su, Ph.D.
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Brian Gregory
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Michael Guo, MD, PhD
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Kaoru Takasaki, MD
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Bin Tian, PhD
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Michael P Hart, PhD
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Golnaz Vahedi, Ph.D.
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Rajan Jain, MD
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Eric F. Joyce, Ph.D.
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Doris Wagner, PhD
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Liling Wan, PhD
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Li-San Wang, Ph.D.
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Rotem Karni, PhD
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Kai Wang, Ph.D.
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Jonathan P. Katz, MD
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Franz Weber, Ph.D.
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Hao Wu, Ph.D.
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Erica Korb, PhD
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Yi Xing, Ph.D.
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Kenneth S Zaret, PhD
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Wanding Zhou, Ph.D.
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Faculty areas of research in G&E can be broken up into the following categories:
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| G&E Faculty | 33Brief Research Description | 8
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| Montserrat Anguera | 8
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Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases 9 |
8
| Naiara Aquizu Lopez | baOur research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders. | 8
| Ben Black | 188Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes | 8
| Kahlilia Blanco | 8
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Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology 9 |
8
| Maja Bucan | 51Genetic dissection of complex behaviors in mice; Functional genomics | 8
| Alice Chen-Plotkin | bbI am interested in neurodegenerative diseases; my research approach uses genomic-scale screens to identify leads for downstream mechanistic follow-up in cell culture systems. | 8
| Gideon Dreyfuss | a4RNA-binding proteins, nuclear transport of proteins and mRNAs, RNA processing, neurodegenerative disease, high throughput approaches to drug discovery. | 8
| Michael Gandal | 8
1c8
The Gandal Lab has three main areas of focus: (1) gene discovery for neurodevelopmental, psychiatric disorders in large-scale biobanks; (2) developing statistical genetic tools and constructing large-scale functional genomic resources using human brain tissue samples to prioritize GWAS mechanisms; (3) using single-cell and long-read sequencing technology to characterize transcript-isoform diversity during human brain development and disease. 9 |
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| Struan Grant | 118Utilizing high-throughput genotyping and sequencing technologies, combined with statistical and bioinformatic approaches, my goals include unraveling genomic puzzles related to childhood obesity, pediatric bone strength determination, early onset diabetes and cancer. | 8
| Michael Guo | 8
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Germline genetics and somatic mosaicism in Alzheimer’s disease and related neurodegenerative disorders 9 |
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| Hakon Hakonarson | 73Genetics of common and rare human diseases, using high-throughput sequencing and genotyping approaches | 8
| Michael Haney | 69Functional genomics of neuroimmune interactions in neurodegenerative disease and brain aging | 8
| Jennifer Kalish | 8
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Understanding and improving detection of epigenetics and mosaicism in human disease 9 |
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| Bryson Katona | a8Understanding cancer risks, prevention strategies, and therapeutic mechanisms for hereditary gastrointestinal cancer and polyposis predisposition syndromes | 8
| Rachel Kember | e8The lab seeks to identify the complex phenotypic and genomic interactions that lead to substance use and psychiatric disease, using computational genetics methods in electronic health record datasets linked to biobanks. | 8
| Edward Lee | 7dNeurogenerative disease pathology, genetics and epigenetics, RNA misprocessing, and human tissue transcriptomics | 8
| Qin Li | 5dGenetic basis of self/non-self RNA discrimination in innate immunity and disease | 8
| Glennis Logsdon | 8
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Genetic and epigenetic variation of complex repeat regions among the human population and throughout evolution using long-read sequencing technologies and synthetic biology approaches 9 |
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| Vikram Paralkar | 63Epigenetics, Transcription, Ribosomal DNA/RNA, Bioinformatics, Hematopoiesis, Leukemia | 8
| Nina Luning Prak | 63Mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition | 8
| Andrew Modzelewski | 61Investigating the role and regulation of retrotransposons in development and disease | 8
| Aimee Payne | a9Genetic and functional characterization of human autoantibody repertoires; Targeted therapy for pemphigus ; Regulation of desmosome assembly and disassembly | 8
| Daniel Rader | 72Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis. | 8
| J. Eric Russell | 42Control and function of human embryonic globin genes. | 8
| Eileen M. Shore | edGenetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes. | 8
| Nancy Spinner | 88Human Genetics, Notch signaling in human disease, Alagille syndrome, human disease gene identifcation by mapping deletions. | 8
| Avi Srivastava | 171The Srivastava Lab focuses on research in three key areas. (1), we design innovative single-cell technologies to explore cellular heterogeneity. (2), we develop high-throughput probabilistic models to quantify single-cell measurements accurately. (3), we apply novel methods to study alternative splicing and chromatin dynamics in hematopoietic disruption. | 8
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Alanna Strong 9 |
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Gene discovery, hepatobiliary disease, cystic kidney disease, ciliopathy syndromes, tubulogenesis | 8
| Kai Tan | 46Model gene regulatory networks in development and disease | 8
| Sarah Tishkoff | 90Human Genetics, complex disease, human evolution, infectious disease, malaria, evolutionary biology, natural selection, adaptation. | 8
| Golnaz Vahedi | 6dEpigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning | 8
| Benjamin Voight | b6Using statistical genetics, population genetics, and computational biology toward understanding the biological underpinnings and evolutionary history of human phenotypes | 8
| Kai Wang | fbWe develop genomics and bioinformatics methods to understand the genetic basis of human diseases, with specific focus on the use of long-read sequencing techniques and the integration of multimodal data from electronic health records | 8
| Other CAMB Faculty | 33Brief Research Description | 8
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| Dwight Stambolian | 3fGene discovery of complex and monogenic disorders. | 8
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| Nancy Bonini | 3dMolecular genetics of neurodegenerative disease. | 8
| Brian Gregory | 51RNA silencing, RNA degradation, RNA stability, microRNAs, small RNAs | 8
| John Murray | 7cDevelopmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans | 8
| David Raizen | 4dThe regulation and purpose of sleep-like behavior in C. elegans. | 8
| Arjun Raj | 5eRNA systems biology, particular as related to non-coding RNAs and cancer biology. | 8
| Priya Sivaramakrishnan | 8dRegulation of fundamental cellular processes (transcription, DNA replication and repair) during embryonic cell fate programming. | 8
| Meera Sundaram | 46Tubulogenesis and Epithelial matrix biology in C. elegans | 8
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| Michael Atchison | 46Control of Gene Expression, development, and oncogenesis. | 8
| Thomas Jongens | 59Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification | 8
| Eric Joyce | 51Form and function of nuclear compartments and chromosome positioning | 8
| Amita Sehgal | 28Molecular basis of behavior | 8
| Other CAMB Faculty | 33Brief Research Description | 8
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| Greg Bashaw | 5eSignaling mechanisms that function during attractive and repulsive axon guidance. | 8
| Sara Cherry | 48Genetic and mechanistic studies of viral-host interactions. | 8
| Steve Dinardo | 3aStem cell function; developmental patterning. | 8
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| Montserrat Anguera | 8
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Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases 9 |
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| Michael Atchison | 46Control of Gene Expression, development, and oncogenesis. | 8
| Marisa Bartolomei | 8
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Genomic imprinting and X inactivation in mice. 9 |
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| Craig Bassing | 10aMy lab uses mice as a model to elucidate genetic, epigenetic, and signaling mechanisms by which organisms establish genetic diversity of lymphocyte antigen receptor genes while suppressing inherent hazards of autoimmunity and lymphoid malignancies | 8
| Ben Black | 188Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes | 8
| Kahlilia Blanco | 8
86
Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology 9 |
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| Edward S. Brodkin | abGenetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia. | 8
| Lewis Chodosh | 8eGenetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging. | 8
| Douglas Epstein | 4eRegulation of Sonic hedgehog signaling in development and disease | 8
| Jonathan Epstein | 5fTranscriptional regulation of cardiac development and function using mouse models. | 8
| Michael Haney | 69Functional genomics of neuroimmune interactions in neurodegenerative disease and brain aging | 8
| Xianxin Hua | 83The critical role of the tumor suppressor Menin in regulation of cell proliferation, apoptosis, and genome stability. 51 Signal transduction mediated by transforming growth factor beta (TGF-b). |
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| Olena Jacenko | 59Molecular mechanisms of skeletal development and blood cell differentiation. | 8
| Brad Johnson | 53Molecular biology of aging, Werner syndrome, telomeres, recombination. | 8
| Eric Joyce | 51Form and function of nuclear compartments and chromosome positioning | 8
| Klaus Kaestner | 116Dr. Kaestner’s lab is employing modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. | 8
| Yana Kamberov | 10eEvolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution | 8
| Anna Kashina | 73Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis. | 8
| Jonathan Katz | 60Transcriptional regulation, epithelial homeostasis, gastrointestinal carcinogenesis | 8
| Frank Lee | 3aMolecular mechanisms of the hypoxic response. | 8
| Carman Li | f8Hereditary cancer development and therapeutics, with a special focus on BRCA1/2 breast cancer; Genetically engineered mice and organoid models; Single-cell Omics; Gene haploinsufficiency; Transcriptional gene regulation and epigenetics | 8
| Andrew Modzelewski | 61Investigating the role and regulation of retrotransposons in development and disease | 8
| Ed Morrisey | 9aLung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors. | 8
| Arghya Mukherjee | 84Emergent properties of the frontal cortex and associated circuits across normal development and mental disorders. | 8
| Kazuko Nishikura | 66RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation. | 8
| Vikram Paralkar | 63Epigenetics, Transcription, Ribosomal DNA/RNA, Bioinformatics, Hematopoiesis, Leukemia | 8
| Michael Parmacek | 4fTranscriptional programs that regulate cardiovascular development. | 8
| Aimee Payne | 58*Genetic and functional characterization of human autoantibody repertoires 29 *Targeted therapy for pemphigus 3a *Regulation of desmosome assembly and disassembly |
8
| Nina Luning Prak | 63mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition | 8
| Daniel Rader | 72Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis. | 8
| J. Eric Russell | 42Control and function of human embryonic globin genes. | 8
| Celeste Simon | 66Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation. | 8
| Nancy Speck | 45Hematopoietic stem cells and leukemia using mouse models | 8
| Avi Srivastava | 171The Srivastava Lab focuses on research in three key areas. (1), we design innovative single-cell technologies to explore cellular heterogeneity. (2), we develop high-throughput probabilistic models to quantify single-cell measurements accurately. (3), we apply novel methods to study alternative splicing and chromatin dynamics in hematopoietic disruption. | 8
| Ben Stanger | 54Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size. | 8
| Doris Stoffers | 123Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin. | 8
| Katalin Susztak | 89Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development | 8
| Kenneth Zaret | 52Mammalian gene regulation, cell differentiation, chromatin structure. | 8
| Zhaolan (Joe) Zhou | 68Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease | 8
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| G&E Faculty | 33Brief Research Description | 8
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| Brian Gregory | 51RNA silencing, RNA degradation, RNA stability, microRNAs, small RNAs | 8
| Doris Wagner | 78Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues. | 8
| Other CAMB Faculty | 33Brief Research Description | 8
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| Scott Poethig | 4dRegulation of developmental timing and organ polarity in plants. | 8
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| Shelley Berger | 136Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection. | 8
| Kara Bernstein | 4fRegulation of DNA repair, recombination, and replication in cancer | 8
| Erfei Bi | 56Development of cell polarity and control of cytokinesis in budding yeast. | 8
| Andrew Dancis | 80Iron transport into mitochondria, Heme synthesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia | 8
| Wei Guo | 84The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis. | 8
| Brad Johnson | 53Molecular biology of aging, Werner syndrome, telomeres, recombination. | 8
| Frank Luca | 45Yeast and mammalian cell cycle regulation; Cytokinesis. 42 Daughter cell-specific gene expression; Polarized growth 68 Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM). |
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| Frederic Bushman | 54Virology, HIV, Poxviruses, DNA modifying enzymes, Lateral DNA transfer. | 8
| Sara Cherry | 48Genetic and mechanistic studies of viral-host interactions. | 8
| Mark Goulian | 42Bacterial regulatory circuits and signal transduction | 8
| Elizabeth Grice | 77Genomic approaches to understand host-microbe interactions at the cutaneous surface in health and disease. | 8
| Paul Lieberman | aeGenome maintenance and gene expression; Gammaherpesviruses and oncogenesis; Telomere Biology, Chromatin structure and genome stability; Transcription regulation. | 8
| Nicole Marino | 8
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Molecular antagonism between bacteria and phage, CRISPR-Cas biology and applications 9 |
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| Mechthild Pohlschroder | 61Prokaryotic Protein Translocation across Hydrophobic Membranes and Their Substrates. | 8
| Alexander Price | 8
b9
Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing , viral and cellular RNA transcription and processing, and viral-host interactions 9 |
8
| David Roos | 122Molecular parasitology, host-pathogen interactions, drug targets & resistance mechanisms, evolution of eukaryotic cells & organellar function, genome databases & database mining, comparative genomics, computational biology, Toxoplasma gondii, Plasmodium falciparum. | 8
| Matthew Weitzman | 62Virology, Virus Replication, DNA Damage and Repair, Genome Instability, Viral Vectors | 8
| Jun Zhu | 4fQuorum Sensing, Bacterial pathogenesis, Biofilms, Vibrio cholerae. | 8
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| G&E Faculty | 33Brief Research Description | 8
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| Naiara Aquizu Lopez | baOur research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders. | 8
| Michael Atchison | 46Control of Gene Expression, development, and oncogenesis. | 8
| Craig Bassing | 10aMy lab uses mice as a model to elucidate genetic, epigenetic, and signaling mechanisms by which organisms establish genetic diversity of lymphocyte antigen receptor genes while suppressing inherent hazards of autoimmunity and lymphoid malignancies | 8
| Roberto Bonasio | 39Epigenetics, chromatin, noncoding RNAs, ants | 8
| Gerd Blobel | 4dHematopoiesis, gene expression, transcription factors, chromatin | 8
| Brian Capell | c0Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system. | 8
| Jennifer Cremins | a0The Cremins lab investigates the link between three-dimensional organization of genomes and the establishment and maintenance of cellular function. | 8
| Douglas Epstein | 4eRegulation of Sonic hedgehog signaling in development and disease | 8
| Michael Gandal | 8
1c8
The Gandal Lab has three main areas of focus: (1) gene discovery for neurodevelopmental, psychiatric disorders in large-scale biobanks; (2) developing statistical genetic tools and constructing large-scale functional genomic resources using human brain tissue samples to prioritize GWAS mechanisms; (3) using single-cell and long-read sequencing technology to characterize transcript-isoform diversity during human brain development and disease. 9 |
8
| Thomas Jongens | 59Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification | 8
| Eric Joyce | 51Form and function of nuclear compartments and chromosome positioning | 8
| Yana Kamberov | 10eEvolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution | 8
| Andrew Modzelewski | 61Investigating the role and regulation of retrotransposons in development and disease | 8
| Ed Morrisey | 9aLung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors. | 8
| Arghya Mukherjee | 84Emergent properties of the frontal cortex and associated circuits across normal development and mental disorders. | 8
| Mary Mullins | 9bBMP signal transduction; molecular mechanisms of cell specification establishment of the vertebrate body plan via maternal control mechanisms. | 8
| John Murray | 89Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging | 8
| Kazuko Nishikura | 66RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation. | 8
| Aimee Payne | 58*Genetic and functional characterization of human autoantibody repertoires 29 *Targeted therapy for pemphigus 3a *Regulation of desmosome assembly and disassembly |
8
| Priya Sivaramakrishnan | 8
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Studying fundamental gene regulatory principles that drive robust cellular decision-making during embryonic development. 9 |
8
| Nancy Spinner | 88Human Genetics, Notch signaling in human disease, Alagille syndrome, human disease gene identifcation by mapping deletions. | 8
| Eileen M. Shore | edGenetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes. | 8
| Doris Stoffers | 123Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin. | 8
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Alanna Strong 9 |
6e
Gene discovery, hepatobiliary disease, cystic kidney disease, ciliopathy syndromes, tubulogenesis | 8
| Meera Sundaram | 46Tubulogenesis and Epithelial matrix biology in C. elegans | 8
| Katalin Susztak | 8aWork in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development. | 8
| Kai Tan | 46Model gene regulatory networks in development and disease | 8
| Doris Wagner | 78Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues. | 8
| Kenneth Zaret | 52Mammalian gene regulation, cell differentiation, chromatin structure. | 8
| Zhaolan (Joe) Zhou | 68Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease | 8
| Other CAMB Faculty | 33Brief Research Description | 8
|---|---|
| Greg Bashaw | 5eSignaling mechanisms that function during attractive and repulsive axon guidance. | 8
| Steve DiNardo | 3aStem Cell Function; developmental patterning. | 8
| Jonathan Epstein | 5fTranscriptional regulation of cardiac development and function using mouse models. | 8
| Michael Granato | 4cAxonal guidance and motor behavior regulation in the zebrafish. | 8
| Olena Jacenko | 59Molecular mechanisms of skeletal development and blood cell differentiation. | 8
| Brian Keith | 66How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression. | 8
| Michael Pack | 5cGenetic analysis of vertebrate digestive organ development using the zebrafish. | 8
| Micahel Parmacek | 4fTranscriptional programs that regulate cardiovascular development. | 8
| Scott Poethig | 4dRegulation of developmental timing and organ polarity in plants. | 8
| Patrick Seale | 48Transcriptional control of adipocyte formation and function | 8
| Celeste Simon | 66Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation. | 8
| Nancy Speck | 45Hematopoietic stem cells and leukemia using mouse models | 8
| Ben Stanger | 54Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size. | 8
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| G&E Faculty | 33Brief Research Description | 8
|---|---|
| Kahlilia Blanco | 8
86
Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology 9 |
8
| Roberto Bonasio | 39Epigenetics, chromatin, noncoding RNAs, ants | 8
| Nancy Bonini | 3dMolecular genetics of neurodegenerative disease. | 8
| Edward S. Brodkin | abGenetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia. | 8
| Maja Bucan | 51Genetic dissection of complex behaviors in mice; Functional genomics | 8
| Alice Chen-Plotkin | bbI am interested in neurodegenerative diseases; my research approach uses genomic-scale screens to identify leads for downstream mechanistic follow-up in cell culture systems. | 8
| Douglas Epstein | 4eRegulation of Sonic hedgehog signaling in development and disease | 8
| Michael Gandal | 8
1c8
The Gandal Lab has three main areas of focus: (1) gene discovery for neurodevelopmental, psychiatric disorders in large-scale biobanks; (2) developing statistical genetic tools and constructing large-scale functional genomic resources using human brain tissue samples to prioritize GWAS mechanisms; (3) using single-cell and long-read sequencing technology to characterize transcript-isoform diversity during human brain development and disease. 9 |
8
| MIchael Guo | 8
73
Germline genetics and somatic mosaicism in Alzheimer’s disease and related neurodegenerative disorders 9 |
8
| Michael Haney | 69Functional genomics of neuroimmune interactions in neurodegenerative disease and brain aging | 8
| Thomas Jongens | 59Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification | 8
| Rachel Kember | e8The lab seeks to identify the complex phenotypic and genomic interactions that lead to substance use and psychiatric disease, using computational genetics methods in electronic health record datasets linked to biobanks. | 8
| Erica Korb | 63Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders | 8
| Edward Lee | 7dNeurogenerative disease pathology, genetics and epigenetics, RNA misprocessing, and human tissue transcriptomics | 8
| Arghya Mukherjee | 84Emergent properties of the frontal cortex and associated circuits across normal development and mental disorders. | 8
| Kazuko Nishikura | 66RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation. | 8
| David Raizen | 4cThe regulation and purpose of sleep-like behavior in C. elegans | 8
| Amita Sehgal | 28Molecular basis of behavior | 8
| Franz Weber | ddWe employ a multidisciplinary approach to study the regulation and function of REM sleep and seek to mechanistically understand how this brain state influences our emotions and behavior in health and disease. | 8
| Zhaolan (Joe) Zhou | 68Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease | 8
| Other CAMB Faculty | 33Brief Research Description | 8
|---|---|
| Greg Bashaw | 5eSignaling mechanisms that function during attractive and repulsive axon guidance. | 8
| Michael Granato | 4cAxonal guidance and motor behavior regulation in the zebrafish. | 8
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| G&E Faculty | 33Brief Research Description | 8
|---|---|
| Yoseph Barash | e3The lab develops machine learning algorithms that integrate high-throughput data (RNASeq, CLIPSeq , PIPSeq, etc.) to infer RNA biogenesis and function, followed by experimental verifications of inferred mechanisms. | 8
| Craig Bassing | 10aMy lab uses mice as a model to elucidate genetic, epigenetic, and signaling mechanisms by which organisms establish genetic diversity of lymphocyte antigen receptor genes while suppressing inherent hazards of autoimmunity and lymphoid malignancies | 8
| Kara Bernstein | 4fRegulation of DNA repair, recombination, and replication in cancer | 8
| Andres Blanco | aeI study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs. | 8
| Gerd Blobel | 4dHematopoiesis, gene expression, transcription factors, chromatin | 8
| Garrett Brodeur | 5aMolecular biology and genetics of childhood cancer, especially neuroblastoma. | 8
| Brian Capell | c0Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system. | 8
| Lewis Chodosh | 8eGenetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging. | 8
| Douglas Epstein | 4eRegulation of Sonic hedgehog signaling in development and disease | 8
| Robert Faryabi | 46Develop analytical methods for precision cancer genomics. | 8
| David Feldser | c3Mechanisms of tumor-suppressor gene action; Role of the immune system in tumor suppression; Genome engineering in the mouse; Chemical genetic strategies to modulate tumor suppression | 8
| Pablo Gonzalez-Camara | 8
a5
The focus of the Camara lab is the application and development of computational methods to study cellular heterogeneity and its role in cancer progression 9 |
8
| Jennifer Kalish | 5eUnderstanding and improvingdetection of epigenetics and mosaicismin human disease | 8
| Bryson Katona | a8Understanding cancer risks, prevention strategies, and therapeutic mechanisms for hereditary gastrointestinal cancer and polyposis predisposition syndromes | 8
| Jonathan Katz | 60Transcriptional regulation, epithelial homeostasis, gastrointestinal carcinogenesis | 8
| Brian Keith | 66How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression. | 8
| Carman Li | f8Hereditary cancer development and therapeutics, with a special focus on BRCA1/2 breast cancer; Genetically engineered mice and organoid models; Single-cell Omics; Gene haploinsufficiency; Transcriptional gene regulation and epigenetics | 8
| Maureen Murphy | cep53 tumor suppressor, HSP70 chaperone, autophagy, programmed cell death. Keywords: Cancer Genetics and Signal Transduction, Genetics of diabetes and metabolism, Animal modeling of human disease | 8
| Warren Pear | 54Processes that control normal development and malignant transformation. | 8
| Anil Rustgi | 6fOncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI). | 8
| Sydney Shaffer | 72Systems biology, genomics, lineage tracing, and spatial transcriptomics applied to tissues and cancer | 8
| Junwei Shi | 69CRISPR genome editing, cancer functional genomics, transcriptional and epigenetic regulation | 8
| Celeste Simon | 66Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation. | 8
| Ben Stanger | 54Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size. | 8
| Doris Stoffers | 123Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin. | 8
| Meera Sundaram | 46Regulation and targets of Ras/ERK signaling in C. elegans | 8
| Kai Tan | 46Model gene regulatory networks in development and disease | 8
| Doris Wagner | 78Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues. | 8
1 45 b
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5a
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| G&E Faculty | 33Brief Research Description | 8
|---|---|
| Xianxin Hua | faElucidating the critical role of the tumor suppressor Menin in regulation of cell proliferation, leukemia and diabetes; investigating signal transduction and epigenetics co-regulated by transforming growth factor beta (TGF-ß) and Menin. | 8
| Klaus Kaestner | faUsing modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. | 8
| Mitchell Lazar | 57Regulation of gene expression and metabolism by nuclear hormone receptors. | 8
| Qin Li | 5dGenetic basis of self/non-self RNA discrimination in innate immunity and disease | 8
| Michael Pack | 3e* Development of the vertebrate digestive system 45 * Biology and physiology of digestive epithelia and cancers 36 * High throughput small molecule drug screens |
8
| Liming Pei | beThe goal of our research is to understand metabolism and metabolic regulation in both normal physiology and disease states and apply this knowledge to human health and medicine. | 8
| Daniel Rader | 72Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis. | 8
| Patrick Seale | 11eWe are particularly interested in early determination and specification events; this involves the commitment of mesenchymal stem cells to a preadipose cell fate. We are also exploring pathways that determine the fate (and thus the function) of different types of fat cells. | 8
| Raymond Soccio | 96Nuclear receptors, transcription factors, lipid metabolism, genetic variation, Fatty liver disease, metabolic syndrome, obesity, diabetes | 8
| Doris Stoffers | 123Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin. | 8
| Katherine Wellen | aaMy lab is studying cellular metabolism, particularly how metabolic pathways regulate signal transduction and gene expression in cancer and metabolic disease. | 8
5
57
5
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1e
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1
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b
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| G&E Faculty | 33Brief Research Description | 8
|---|---|
| Montserrat Anguera | 8
6b
Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases 9 |
8
| Naiara Aquizu Lopez | baOur research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders. | 8
| Andres Blanco | aeI study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs. | 8
| Kahlilia Blanco | 8
86
Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology 9 |
8
| Nancy Bonini | 3dMolecular genetics of neurodegenerative disease. | 8
| Edward S. Brodkin | abGenetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia. | 8
| Maja Bucan | 52Genetic dissection of complex behaviors in mice; functional genomics. | 8
| Brian Capell | c0Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system. | 8
| Lewis Chodosh | 8eGenetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging. | 8
| Gideon Dreyfuss | a4RNA-binding proteins, nuclear transport of proteins and mRNAs, RNA processing, neurodegenerative disease, high throughput approaches to drug discovery. | 8
| Douglas Epstein | 4eRegulation of Sonic hedgehog signaling in development and disease | 8
| David Feldser | c3Mechanisms of tumor-suppressor gene action; Role of the immune system in tumor suppression; Genome engineering in the mouse; Chemical genetic strategies to modulate tumor suppression | 8
| Michael Haney | 69Functional genomics of neuroimmune interactions in neurodegenerative disease and brain aging | 8
| Thomas Jongens | 59Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification | 8
| Klaus Kaestner | faUsing modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. | 8
| Yana Kamberov | 10eEvolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution | 8
| Bryson Katona | d3Using mouse models of hereditary gastrointestinal cancer and polyposis predisposition syndromes to understand cancer risks, prevention strategies, and therapeutic mechanisms for these syndromes | 8
| Jonathan Katz | 60Transcriptional regulation, epithelial homeostasis, gastrointestinal carcinogenesis | 8
| Erica Korb | 63Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders | 8
| Mitchell Lazar | 59* Regulation of gene expression and metabolism by nuclear hormone receptors 4a * Mechanism of obesity-associated insulin resistance and diabetes |
8
| Carman Li | f8Hereditary cancer development and therapeutics, with a special focus on BRCA1/2 breast cancer; Genetically engineered mice and organoid models; Single-cell Omics; Gene haploinsufficiency; Transcriptional gene regulation and epigenetics | 8
| Arghya Mukherjee | 84Emergent properties of the frontal cortex and associated circuits across normal development and mental disorders. | 8
| Aimee Payne | 58*Genetic and functional characterization of human autoantibody repertoires 29 *Targeted therapy for pemphigus 3a *Regulation of desmosome assembly and disassembly |
8
| Nina Luning Prak | 63Mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition | 8
| J. Eric Russell | 42Control and function of human embryonic globin genes. | 8
| Priya Sivaramakrishnan | 8
a4
Generation of humanized worms to examine the molecular basis of variable expressivity and penetrance in transcription-associated developmental disorders. 9 |
8
| Eileen M. Shore | edGenetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes. | 8
| Raymond Soccio | 96Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes | 8
| Doris Stoffers | 123Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin. | 8
| Meera Sundaram | 46Tubulogenesis and Epithelial matrix biology in C. elegans | 8
| Katalin Susztak | 89Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development | 8
| Zhaolan (Joe) Zhou | 68Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease | 8
| Other CAMB Faculty | 33Brief Research Description | 8
|---|---|
| Jonathan Epstein | 5fTranscriptional regulation of cardiac development and function using mouse models. | 8
| Brad Johnson | 53Molecular biology of aging, Werner syndrome, telomeres, recombination. | 8
| Brian Keith | 66How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression. | 8
| Warren Pear | 54Processes that control normal development and malignant transformation. | 8
| Celeste Simon | 66Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation. | 8
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| G&E Faculty | 33Brief Research Description | 8
|---|---|
| Montserrat Anguera | 8
6b
Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases 9 |
8
| Michael Atchison | 46Control of Gene Expression, development, and oncogenesis. | 8
| Marisa Bartolomei | 3bGenomic imprinting and X inactivation in mice. | 8
| Craig Bassing | 10aMy lab uses mice as a model to elucidate genetic, epigenetic, and signaling mechanisms by which organisms establish genetic diversity of lymphocyte antigen receptor genes while suppressing inherent hazards of autoimmunity and lymphoid malignancies | 8
| Shelley Berger | 136Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection. | 8
| Andres Blanco | aeI study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs. | 8
| Kahlilia Blanco | 8
86
Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology 9 |
8
| Gerd Blobel | 4dhematopoiesis, gene expression, transcription factors, chromatin | 8
| Roberto Bonasio | 5eMolecular mechanisms of epigenetic memory, Noncoding RNAs, Chromatin biochemistry | 8
| Brian Capell | c0Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system. | 8
| Douglas Epstein | 4eRegulation of Sonic hedgehog signaling in development and disease | 8
| Jonathan Epstein | 5fTranscriptional regulation of cardiac development and function using mouse models. | 8
| Robert Faryabi | 6eModel interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer | 8
| Michael Gandal | 8
1c8
The Gandal Lab has three main areas of focus: (1) gene discovery for neurodevelopmental, psychiatric disorders in large-scale biobanks; (2) developing statistical genetic tools and constructing large-scale functional genomic resources using human brain tissue samples to prioritize GWAS mechanisms; (3) using single-cell and long-read sequencing technology to characterize transcript-isoform diversity during human brain development and disease. 9 |
8
| Alessandro Gardini | b4The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches. | 8
| Michael Guo | 8
73
Germline genetics and somatic mosaicism in Alzheimer’s disease and related neurodegenerative disorders 9 |
8
| Eric Joyce | 51Form and function of nuclear compartments and chromosome positioning | 8
| Klaus Kaestner | faUsing modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. | 8
| Jonathan Katz | 60Transcriptional regulation, epithelial homeostasis, gastrointestinal carcinogenesis | 8
| Erica Korb | 63Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders | 8
| Melike Lakadamyali | 67Super-resolution imaging of chromatin structure and epigenetic regulation of gene activity | 8
| Mitchell Lazar | 57Regulation of gene expression and metabolism by nuclear hormone receptors. | 8
| Frank Lee | 3aMolecular mechanisms of the hypoxic response. | 8
| Carman Li | f8Hereditary cancer development and therapeutics, with a special focus on BRCA1/2 breast cancer; Genetically engineered mice and organoid models; Single-cell Omics; Gene haploinsufficiency; Transcriptional gene regulation and epigenetics | 8
| Ronen Marmorstein | f2Biochemical, biophysical and X-ray crystallographic techniques are employed to study the posttranslational modification of histones and other proteins and the misregulation of such modifications in cancer and metabolic disorders. | 8
| Andrew Modzelewski | 61Investigating the role and regulation of retrotransposons in development and disease | 8
| Arghya Mukherjee | 84Emergent properties of the frontal cortex and associated circuits across normal development and mental disorders. | 8
| John Murray | 7cDevelopmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans | 8
| Vikram Paralkar | 63Epigenetics, Transcription, Ribosomal DNA/RNA, Bioinformatics, Hematopoiesis, Leukemia | 8
| Jennifer Phillips-Cremins | 8bEpigenetics | Genomics | Systems and Synthetic Bioengineering | Experimental Neuroscience | Molecular and Cellular Engineering | 8
| Alexander Price | 8
b9
Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing , viral and cellular RNA transcription and processing, and viral-host interactions 9 |
8
| Kavitha Sarma | 53RNA interactions in epigenetic gene regulation and genome organization | 8
| Sydney Shaffer | 72Systems biology, genomics, lineage tracing, and spatial transcriptomics applied to tissues and cancer | 8
| Junwei Shi | 69CRISPR genome editing, cancer functional genomics, transcriptional and epigenetic regulation | 8
| Eileen M. Shore | edGenetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes. | 8
| Rebecca Simmons | b0Developmental programming of adult disease (diabetes, obesity); ß-cell development; role of epigenetics in fetal programming and early embryo/placenta development | 8
| Priya Sivaramakrishnan | 8
75
Developing omics and imaging tools to capture and visualize gene regulatory phenomenon at high-resolution. 9 |
8
| Avi Srivastava | 171The Srivastava Lab focuses on research in three key areas. (1), we design innovative single-cell technologies to explore cellular heterogeneity. (2), we develop high-throughput probabilistic models to quantify single-cell measurements accurately. (3), we apply novel methods to study alternative splicing and chromatin dynamics in hematopoietic disruption. | 8
|
18
Alanna Strong 9 |
6e
Gene discovery, hepatobiliary disease, cystic kidney disease, ciliopathy syndromes, tubulogenesis | 8
| Meera Sundaram | 46Regulation and targets of Ras/ERK signaling in C. elegans | 8
| Kai Tan | 46Model gene regulatory networks in development and disease | 8
| Golnaz Vahedi | 6dEpigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning | 8
| Doris Wagner | 78Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues. | 8
| Kenneth Zaret | 52Mammalian gene regulation, cell differentiation, chromatin structure. | 8
| Zhaolan (Joe) Zhou | 68Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease | 8
| Other CAMB Faculty | 33Brief Research Description | 8
|---|---|
| Brian Keith | 66How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression. | 8
| Michael Parmacek | 4fTranscriptional programs that regulate cardiovascular development. | 8
| Celeste Simon | 66Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation. | 8
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| G&E Faculty | 33Brief Research Description | 8
|---|---|
| Naiara Aquizu Lopez | baOur research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders. | 8
| Michael Atchison | 46Control of Gene Expression, development, and oncogenesis. | 8
| Yoseph Barash | e2The lab develops machine learning algorithms that integrate high-throughput data (RNASeq, CLIPSeq, PIPSeq, etc.) to infer RNA biogenesis and function, followed by experimental verifications of inferred mechanisms. | 8
| Kahlilia Blanco | 8
86
Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology 9 |
8
| Gideon Dreyfuss | a4RNA-binding proteins, nuclear transport of proteins and mRNAs, RNA processing, neurodegenerative disease, high throughput approaches to drug discovery. | 8
| Brian Gregory | 51RNA silencing, RNA degradation, RNA stability, microRNAs, small RNAs | 8
| Thomas Jongens | 59Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification | 8
| Eric Joyce | 51Form and function of nuclear compartments and chromosome positioning | 8
| Mitchell Lazar | 57Regulation of gene expression and metabolism by nuclear hormone receptors. | 8
| Frank Lee | 39Molecular mechanisms of the hypoxic response | 8
| Qin Li | 5dGenetic basis of self/non-self RNA discrimination in innate immunity and disease | 8
| Kristin Lynch | b7Mechanisms and consequences of alternative pre-mRNA splicing, in particular, how splicing patterns change in T cells during an immune response to alter cellular function. | 8
| Zissimos Mourelatos | 29MicroRNAs, RNA interference. | 8
| John Murray | 7cDevelopmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans | 8
| Alexander Price | 8
b8
Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing, viral and cellular RNA transcription and processing, and viral-host interactions 9 |
8
| Doris Stoffers | 123Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin. | 8
| Kazuko Nishikura | 66RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation. | 8
| J. Eric Russell | 42Control and function of human embryonic globin genes. | 8
| Zhaolan (Joe) Zhou | 68Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease | 8
| Other CAMB Faculty | 33Brief Research Description | 8
|---|---|
| Constantinos Koumenis | 63Tumor hypoxia, Unfolded Protein Response, translational regulation of gene expression. | 8
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| G&E Faculty | 33Brief Research Description | 8
|---|---|
| Montserrat Anguera | 8
6b
Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases 9 |
8
| Michael Atchison | 46Control of Gene Expression, development, and oncogenesis. | 8
| Marisa Bartolomei | 3bGenomic imprinting and X inactivation in mice. | 8
| Craig Bassing | 10aMy lab uses mice as a model to elucidate genetic, epigenetic, and signaling mechanisms by which organisms establish genetic diversity of lymphocyte antigen receptor genes while suppressing inherent hazards of autoimmunity and lymphoid malignancies | 8
| Shelley Berger | 136Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection. | 8
| Kara Bernstein | 4fRegulation of DNA repair, recombination, and replication in cancer | 8
| Ben Black | 188Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes | 8
| Andres Blanco | aeI study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs. | 8
| Kahlilia Blanco | 8
86
Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology 9 |
8
| Gerd Blobel | 4dHematopoiesis, gene expression, transcription factors, chromatin | 8
| Roberto Bonasio | 5eMolecular mechanisms of epigenetic memory, Noncoding RNAs, Chromatin biochemistry | 8
| Brian Capell | c0Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system. | 8
| Maya Capelson | 40*Nuclear structure and its role in gene regulation 2d *Spatial organization of the genome 35 *Epigenetic memory of gene expression states |
8
| Jennifer Cremins | a0The Cremins lab investigates the link between three-dimensional organization of genomes and the establishment and maintenance of cellular function. | 8
| Jonathan Epstein | 5fTranscriptional regulation of cardiac development and function using mouse models. | 8
| Robert Faryabi | 6eModel interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer | 8
| David Feldser | c3Mechanisms of tumor-suppressor gene action; Role of the immune system in tumor suppression; Genome engineering in the mouse; Chemical genetic strategies to modulate tumor suppression | 8
| Alessandro Gardini | b3The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches | 8
| Eric Joyce | 51Form and function of nuclear compartments and chromosome positioning | 8
| Klaus Kaestner | faUsing modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. | 8
| Jennifer Kalish | 60Understanding and improving detection of epigenetics and mosaicism in human disease | 8
| Brett Kaufman | 80The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission. | 8
| Peter Klein | 67Early vertebrate development, Wnt signal transduction, neuropharmacology of lithium action | 8
| Erica Korb | 63Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders | 8
| Melike Lakadamyali | 9dThe Lakadamyali lab uses high resolution, single cell imaging technologies to investigate the link between genome organization and gene function | 8
| Mitchell Lazar | 57Regulation of gene expression and metabolism by nuclear hormone receptors. | 8
| Edward Lee | 7dNeurogenerative disease pathology, genetics and epigenetics, RNA misprocessing, and human tissue transcriptomics | 8
| Carman Li | f8Hereditary cancer development and therapeutics, with a special focus on BRCA1/2 breast cancer; Genetically engineered mice and organoid models; Single-cell Omics; Gene haploinsufficiency; Transcriptional gene regulation and epigenetics | 8
| Stephen Liebhaber | baRoles of chromatin structure and epigenetic controls in eucaryotic gene activation; Roles of mRNA-protein interactions in control of eucarytic mRNA stability and expression. | 8
| Glennis Logsdon | c9Genetic and epigenetic variation of complex repeat regions among the human population and throughout evolution using long-read sequencing technologies and synthetic biology approaches | 8
| John Murray | 7cDevelopmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans | 8
| Vikram Paralkar | 63Epigenetics, Transcription, Ribosomal DNA/RNA, Bioinformatics, Hematopoiesis, Leukemia | 8
| John R. Pehrson | 54Role of histone variants in regulating chromatin structure and function | 8
| Kavitha Sarma | 53RNA interactions in epigenetic gene regulation and genome organization | 8
| Richard Schultz | 41Egg activation and gene expression in mouse embryos. | 8
| Sydney Shaffer | 72Systems biology, genomics, lineage tracing, and spatial transcriptomics applied to tissues and cancer | 8
| Junwei Shi | 69CRISPR genome editing, cancer functional genomics, transcriptional and epigenetic regulation | 8
| Eileen M. Shore | edGenetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes. | 8
| Rebecca Simmons | b0Developmental programming of adult disease (diabetes, obesity); ß-cell development; role of epigenetics in fetal programming and early embryo/placenta development | 8
| Raymond Soccio | 96Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes | 8
| Avi Srivastava | 171The Srivastava Lab focuses on research in three key areas. (1), we design innovative single-cell technologies to explore cellular heterogeneity. (2), we develop high-throughput probabilistic models to quantify single-cell measurements accurately. (3), we apply novel methods to study alternative splicing and chromatin dynamics in hematopoietic disruption. | 8
| Doris Stoffers | 123Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin. | 8
| Kai Tan | 46Model gene regulatory networks in development and disease | 8
| Golnaz Vahedi | 6dEpigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning | 8
| Doris Wagner | 78Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues. | 8
| Hao Wu | b6Epigenomics, DNA methylation and demethylation, Transcriptional control, Single cell analysis, Stem cell biology, Neural and cardiac lineage specification and maturation | 8
| Kenneth Zaret | 52Mammalian gene regulation, cell differentiation, chromatin structure. | 8
| Zhaolan Zhou | 53Epigenetic Control of Genome Function in Brain Development and Disease | 8
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| G&E Faculty | 33Brief Research Description | 8
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| Montserrat Anguera | 8
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Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases 9 |
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| Yoseph Barash | e3The lab develops machine learning algorithms that integrate high-throughput data (RNASeq, CLIPSeq , PIPSeq, etc.) to infer RNA biogenesis and function, followed by experimental verifications of inferred mechanisms. | 8
| Ben Black | 188Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes | 8
| Andres Blanco | aeI study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs. | 8
| Roberto Bonasio | 5eMolecular mechanisms of epigenetic memory, Noncoding RNAs, Chromatin biochemistry | 8
| Maja Bucan | 51Genetic dissection of complex behaviors in mice; Functional genomics | 8
| Frederic Bushman | 54Virology, HIV, Poxviruses, DNA modifying enzymes, Lateral DNA transfer. | 8
| Brian Capell | c0Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system. | 8
| Alice Chen-Plotkin | b9I am interested in neurogenerative diseases; my research approach uses genomic-scale screens to identify leads for downstream mechanistic follow-up in cell culture systems. | 8
| Sara Cherry | 48Genetic and mechanistic studies of viral-host interactions. | 8
| Robert Faryabi | 6eModel interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer | 8
| Michael Gandal | 8
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The Gandal Lab has three main areas of focus: (1) gene discovery for neurodevelopmental, psychiatric disorders in large-scale biobanks; (2) developing statistical genetic tools and constructing large-scale functional genomic resources using human brain tissue samples to prioritize GWAS mechanisms; (3) using single-cell and long-read sequencing technology to characterize transcript-isoform diversity during human brain development and disease. 9 |
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| Alessandro Gardini | b3The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches | 8
| Pablo Gonzalez-Camara | 8
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The focus of the Camara lab is the application and development of computational methods to study cellular heterogeneity and its role in cancer progression 9 |
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| Struan Grant | 75My current work continues to primarily investigate disease genomics, with a specific focus on pediatrics | 8
| Michael Guo | 8
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Germline genetics and somatic mosaicism in Alzheimer’s disease and related neurodegenerative disorders 9 |
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| Hakon Hakonarson | 74Genetics of common and rare human diseases, using high-throughput sequencing and genotyping approaches. | 8
| Michael Haney | 69Functional genomics of neuroimmune interactions in neurodegenerative disease and brain aging | 8
| Eric Joyce | 51Form and function of nuclear compartments and chromosome positioning | 8
| Klaus Kaestner | faUsing modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. | 8
| Rachel Kember | e8The lab seeks to identify the complex phenotypic and genomic interactions that lead to substance use and psychiatric disease, using computational genetics methods in electronic health record datasets linked to biobanks. | 8
| Erica Korb | 63Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders | 8
| Edward Lee | 7dNeurogenerative disease pathology, genetics and epigenetics, RNA misprocessing, and human tissue transcriptomics | 8
| Carman Li | f8Hereditary cancer development and therapeutics, with a special focus on BRCA1/2 breast cancer; Genetically engineered mice and organoid models; Single-cell Omics; Gene haploinsufficiency; Transcriptional gene regulation and epigenetics | 8
| Qin Li | 5dGenetic basis of self/non-self RNA discrimination in innate immunity and disease | 8
| Glennis Logsdon | fcDevelopment of software to build complete, telomere-to-telomere human genome assemblies using long-read sequencing technologies and to characterize the variation of complex repeat regions among the human population and throughout evolution | 8
| Arghya Mukerjee | 84Emergent properties of the frontal cortex and associated circuits across normal development and mental disorders. | 8
| John Murray | 7cDevelopmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans | 8
| Vikram Paralkar | 63Epigenetics, Transcription, Ribosomal DNA/RNA, Bioinformatics, Hematopoiesis, Leukemia | 8
| Jennifer Phillips-Cremins | 8bEpigenetics | Genomics | Systems and Synthetic Bioengineering | Experimental Neuroscience | Molecular and Cellular Engineering | 8
| David Roos | 122Molecular parasitology, host-pathogen interactions, drug targets & resistance mechanisms, evolution of eukaryotic cells & organellar function, genome databases & database mining, comparative genomics, computational biology, Toxoplasma gondii, Plasmodium falciparum. | 8
| Sydney Shaffer | 72Systems biology, genomics, lineage tracing, and spatial transcriptomics applied to tissues and cancer | 8
| Junwei Shi | 69CRISPR genome editing, cancer functional genomics, transcriptional and epigenetic regulation | 8
| Raymond Soccio | 96Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes | 8
| Avi Srivastava | 171The Srivastava Lab focuses on research in three key areas. (1), we design innovative single-cell technologies to explore cellular heterogeneity. (2), we develop high-throughput probabilistic models to quantify single-cell measurements accurately. (3), we apply novel methods to study alternative splicing and chromatin dynamics in hematopoietic disruption. | 8
| Doris Stoffers | 123Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin. | 8
| Kai Tan | 46Model gene regulatory networks in development and disease | 8
| Golnaz Vahedi | 6dEpigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning | 8
| Benjamin Voight | b6Using statistical genetics, population genetics, and computational biology toward understanding the biological underpinnings and evolutionary history of human phenotypes | 8
| Doris Wagner | 78Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues. | 8
| Kai Wang | fbWe develop genomics and bioinformatics methods to understand the genetic basis of human diseases, with specific focus on the use of long-read sequencing techniques and the integration of multimodal data from electronic health records | 8
| Kenneth Zaret | 52Mammalian gene regulation, cell differentiation, chromatin structure. | 8
| Zhaolan (Joe) Zhou | 68Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease | 8
| Jun Zhu | 4fQuorum Sensing, Bacterial pathogenesis, Biofilms, Vibrio cholerae. | 8
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For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.
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